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Antibacterial Activity and DNA Interaction of the Pd(bpy)(ONO2)2 Coordination Complex

Corresponding Author : Muhammad Younus (myounus-che@sust.edu)

Authors : Mahmudul H. Suhag (suhag.che057@gmail.com), K. M. Anis-Ul-Haque (anissust@gmail.com), Belal Ahmed (bahmed2021@gmail.com)

Keywords : Palladium complex, DNA binding, absorption titration, antibacterial activity, disk diffusion method

Abstract :

Antibacterial activity of Pd(bpy)(ONO2)2 complex (bpy = bipyridine) was studied by disc diffusion method against Escherichia coli, Staphylococcus aureus, Klebsiella oxytoca, Pseudomonas aeruginosa and Enterococcus faecalis. The compound was found to be active against the bacteria. DNA binding constant of that complex was studied with extracted DNA from lemon by UV-Vis spectroscopy. The calculated binding strength was found to be 2.09×106 which is significantly higher than that of the [Pd(bpy)(OH2)2] 2+ complex with CT-DNA.

Published on June 30th, 2014 in Volume 21, Issue 1, Applied Sciences and Technology